Multiple Query Loops - Duplicated Posts

I’m experimenting with building a new front page to my site using query loops, kind of like how WPSP used to be used.

If I have multiple query loop blocks on the same page, is there a way to make sure that they do not show the same post multiple times on the same page?

I know there is the offset parameter, which works fine for doing this when the query loops are the same but the design changes. Like having a larger featured post at the top.

My Scenario is more like having a 6 posts displayed at the top of the page. Then having additional loops further down the page that are only showing posts from specific categories. If any of my first 6 posts are also in those categories, they show up twice on the front page. Once in the “latest posts” section and once again in the category loops.